DUSP4 anticorps

N° du produit ABIN6569333

L’anticorps Lapin Polyclonal anti-DUSP4 a été validé pour WB. Il convient pour détecter DUSP4 dans des échantillons de Humain et Singe.

Aperçu rapide pour DUSP4 anticorps (ABIN6569333)

Antigène: DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))

Reactivité: Humain, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DUSP4 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-DUSP4 anticorps

Purification: Affinity purification

Immunogène: Recombinant protein of human DUSP4

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur DUSP4

Antigène: DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))

Autre désignation: MKP-2

Sujet:

Synonyms: Dual specificity phosphatase 4,Dual specificity protein phosphatase 4,Dual specificity protein phosphatase hVH2,DUS4,DUSP 4,Dusp4,HVH 2,HVH2,MAP kinase phosphatase 2,Mitogen activated protein kinase phosphatase 2,Mitogen-activated protein kinase phosphatase 2,MKP 2,MKP-2,MKP2,Serine/threonine specific protein phosphatase,TYP,Typ1,VH 2,VH1 homologous phosphatase 2,VH2

Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.

Poids moléculaire:

Observed_MW: 43kDa

Calculated_MW: 32kDa/42kDa

ID gène: 1846

UniProt: Q13115

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades